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Equus caballus (horse) eca-miR-146a URS000050B527_9796

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eca-mir-146a: Eca-mir-146a is a type of microRNA that has been found to play a role in reducing inflammation in adipocytes by targeting factors involved in p38/JNK mediated inflammation [PMC7995974]. In a study, it was demonstrated that the expression of eca-mir-146a was significantly increased between days 42 and 63 and 56 and 63 [PMC9393553]. This study also identified five other microRNAs, including eca-mir-146a, that showed significant changes in expression [PMC9393553]. Real-time PCR was used to validate the expression of eca-mir-146a, along with two other microRNAs (eca-miR-26 and eca-miR-223), in both microvesicles (MVs) and counterpart cells [PMC6434479]. The expression levels of eca-miR-26, eca-mir-146a, and eca-miR-223 were found to be different between MVs and cells, with fold change ratios of 0.68, 4.72, and 16.13 respectively [PMC6434479]. Furthermore, RNA sequencing data showed that while eca-miR-223 was only observed in MVs, both eca-miR26 and eca-mir-146a were present in both MVs and cells with different count ratios [PMC6434479]. In summary, the research suggests that the expression of eca-mir-146a is increased during certain time periods. This microRNA along with others may play a role in regulating inflammation. The levels of these microRNAs can be detected using specific primers through real-time PCR, and their expression can vary between microvesicles and cells [PMC7995974] [PMC9393553] [PMC6434479].

Genome locations

Gene Ontology annotations


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This sequence is found in 20 other species

  1. Alligator mississippiensis Ami-Mir-146-P4_5p (mature (guide))
  2. Callithrix jacchus (white-tufted-ear marmoset) cja-miR-146a
  3. Canis lupus familiaris (dog) cfa-miR-146a
  4. Cervus elaphus (red deer) cel-miR-146a
  5. Cricetulus griseus (Chinese hamster) cgr-miR-146a
  6. Gallus gallus gga-miR-146a-5p
  7. Homo sapiens hsa-miR-146a-5p
  8. Macaca mulatta mml-miR-146a-5p
  9. Microcebus murinus (gray mouse lemur) mmr-miR-146a
  10. Monodelphis domestica mdo-miR-146a-5p
  11. Mus musculus (house mouse) mmu-miR-146a-5p
  12. Nomascus leucogenys (northern white-cheeked gibbon) nle-miR-146a
  13. Pan troglodytes ptr-miR-146a
  14. Papio hamadryas (hamadryas baboon) pha-miR-146a
  15. Pongo pygmaeus (Bornean orangutan) ppy-miR-146a
  16. Pteropus alecto pal-miR-146a-5p
  17. Rattus norvegicus (Norway rat) rno-miR-146a-5p
  18. Sus scrofa (pig) ssc-miR-146a-5p
  19. Taeniopygia guttata (zebra finch) tgu-miR-146c
  20. Tupaia chinensis tch-miR-146a-5p