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bta-mir-185: bta-mir-185 is a microRNA identified in bovine milk exosomes, which remained constant in expression between day 9 and day 16 after S. aureus infection [PMC5487392]. It is known to target specific genes, including DYRK1B, MLLT3, HP1BP3, NPR2, and PGM1 [PMC6896338]. The expression of bta-mir-185 was significantly up-regulated in exosomes from bovine milk infected by S. aureus [PMC6896338], and it was one of the microRNAs with the highest number of predicted target genes (515 genes) [PMC6896338]. The functional relevance of bta-mir-185 was further supported by the down-regulation of luciferase activities in vectors containing the 3′-UTR sequences of its target genes [PMC6896338]. Additionally, bta-mir-185 showed increased expression in milk from cows infected with S. aureus compared to healthy cows [PMC8578396], highlighting its potential role as a biomarker for infection or as a participant in the host's response to infection.
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