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Sus scrofa (pig) ssc-miR-185 URS00004176D4_9823

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ssc-mir-185: ssc-mir-185 is a microRNA that has been associated with various cancers, including gastric cancer [PMC10122348]. It has also been found to play a regulatory role in immune inflammatory responses [PMC10122348]. In a ceRNA network, ssc-mir-185 was found to bind with two downregulated circRNAs (circ-FBXW4, circ-ZEB1) and target MYLK and FN1 for regulation [PMC10122348]. Additionally, ssc-mir-185 has been shown to play a regulatory role in piglet diarrhea [PMC10122348]. In a study on E. coli F18-susceptible pigs, ssc-mir-185 was one of the miRNAs that were upregulated and regulated by different transcription factors [PMC3427155]. It was also found that ssc-mir-185, along with other miRNAs, inhibited the process of host T cell differentiation [PMC6354428]. Furthermore, ssc-mir-185 was shown to regulate the greatest number of target genes among the miRNAs studied [PMC6354428]. CDC42, CXCL12, VEGFD, CCL25, CXCL14, and CXCL16 were potentially regulated by ssc-mir-185 in leukocyte migration and chemokine activity [PMC8851844]. Additionally, IL17F/IL17RC were potentially commonly regulated by ssc-mir-185 with different expression patterns at different time points [PMC8851844]. In adipocyte differentiation processes, ssc-mir-185 was found to be one of the miRNAs involved in regulation [PMC8834144]. ssc-mir-185 has also been studied in relation to Clostridium perfringens type C infection in piglets with diarrhea. It was differentially expressed between resistant and susceptible groups of piglets with diarrhea and may be involved in binding CDC42 for potential mechanisms of action [PMC8100468]. The mature sequence of miR-185 is highly conserved among vertebrates [PMC8100468]. In another study, ssc-mir-185 was found to be up-regulated in the resistance group of piglets with diarrhea [PMC8100468]. Finally, ssc-mir-185 was one of the miRNAs that were randomly selected for verification of miRNA sequencing data in a study on liver function efficiency [PMC9039951].

Genome locations

Gene Ontology annotations

Sequence

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UGGAGAGAAAGGCAGUUCCUGA

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This sequence is found in 18 other species

  1. Bos taurus (cattle) bta-miR-185
  2. Callithrix jacchus (white-tufted-ear marmoset) cja-miR-185
  3. Canis lupus familiaris (dog) cfa-miR-185
  4. Cavia porcellus (domestic guinea pig) cpo-miR-185-5p
  5. Cervus elaphus (red deer) cel-miR-185
  6. Cricetulus griseus (Chinese hamster) cgr-miR-185-5p
  7. Dasypus novemcinctus dno-miR-185-5p
  8. Gorilla gorilla gorilla ggo-miR-185 (MIR185)
  9. Gorilla gorilla (western gorilla) ggo-miR-185
  10. Homo sapiens (human) hsa-miR-185-5p
  11. Macaca mulatta (Rhesus monkey) mml-miR-185-5p
  12. Mus musculus mmu-miR-185-5p
  13. Oryctolagus cuniculus ocu-miR-185-5p
  14. Pan troglodytes ptr-miR-185
  15. Pongo pygmaeus (Bornean orangutan) ppy-miR-185
  16. Pteropus alecto pal-miR-185-5p
  17. Rattus norvegicus (Norway rat) rno-miR-185-5p
  18. Tupaia chinensis (Chinese tree shrew) tch-miR-185-5p
Publications