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Gallus gallus (chicken) gga-miR-146a-5p URS000050B527_9031

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gga-mir-146a: Gga-mir-146a is a differentially expressed miRNA that has been associated with virus infection in both broiler and layer chickens [PMC3496578]. It is one of the miRNAs that are up-regulated after avian influenza virus infection [PMC5389138]. Gga-mir-146a has been found to be involved in the regulation of 3T3-L1 differentiation and adipocyte differentiation [PMC6826404]. It has also been shown to target ESRP2 genes, potentially influencing the postnatal liver maturation process [PMC5758705]. In addition, gga-mir-146a is one of the miRNAs that are up-regulated in CD40L-stimulated B cells, indicating its role in the immune system [PMC3743212]. The expression of gga-mir-146a can be validated using a dual luciferase reporter assay and qPCR [PMC3496578] [PMC8633681]. However, it is not predicted to target chicken IL-2 [PMC2873332]. Overall, gga-mir-146a is a differentially expressed miRNA with potential roles in virus infection, adipocyte differentiation, liver maturation process, and immune system regulation.

Genome locations

Gene Ontology annotations


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This sequence is found in 20 other species

  1. Alligator mississippiensis Ami-Mir-146-P4_5p (mature (guide))
  2. Callithrix jacchus (white-tufted-ear marmoset) cja-miR-146a
  3. Canis lupus familiaris (dog) cfa-miR-146a
  4. Cervus elaphus (red deer) cel-miR-146a
  5. Cricetulus griseus (Chinese hamster) cgr-miR-146a
  6. Equus caballus eca-miR-146a
  7. Homo sapiens hsa-miR-146a-5p
  8. Macaca mulatta mml-miR-146a-5p
  9. Microcebus murinus (gray mouse lemur) mmr-miR-146a
  10. Monodelphis domestica mdo-miR-146a-5p
  11. Mus musculus (house mouse) mmu-miR-146a-5p
  12. Nomascus leucogenys (northern white-cheeked gibbon) nle-miR-146a
  13. Pan troglodytes ptr-miR-146a
  14. Papio hamadryas (hamadryas baboon) pha-miR-146a
  15. Pongo pygmaeus (Bornean orangutan) ppy-miR-146a
  16. Pteropus alecto pal-miR-146a-5p
  17. Rattus norvegicus (Norway rat) rno-miR-146a-5p
  18. Sus scrofa (pig) ssc-miR-146a-5p
  19. Taeniopygia guttata (zebra finch) tgu-miR-146c
  20. Tupaia chinensis tch-miR-146a-5p