ocu-mir-205: ocu-mir-205 is a microRNA that plays a crucial role in regulating hair follicle development and hair density in Rex rabbits [PMC7178635]. It suppresses the expression of Notch signaling pathway genes, including Notch1, Jagged1, Hes1, and Hes5 [PMC7178635]. It induces the expression of BMP signaling pathway genes such as BMP2, BMP4, and TGF-β1 [PMC7178635]. ocu-mir-205 induces G0/G1 arrest in dermal papilla cells (DPCs) and increases apoptosis rates [PMC7178635]. It alters the levels of phosphorylated CTNNB1, GSK-3β, Akt proteins, and NOG protein [PMC7178635]. Furthermore, ocu-mir-205 affects cell proliferation and cell cycle progression [PMC7178635]. It is highly expressed in DPCs compared to other microRNAs analyzed [PMC7178635]. ocu-mir-205 also inhibits the expression of genes involved in the PI3K/Akt signaling pathway such as Inppl1, Frk, and Phlda3 mRNAs [PMC7178635]. Additionally, it inhibits gene expression in Wnt signaling pathway components including Wnt10b CTNNB1 and GSK-3β genes while inducing DKK1 mRNA expression [PMC7178635]. In Rex rabbits with different hair densities, ocu-mir-205 expression differs significantly between dermal papilla cells (DPCs) from rabbits with high versus low hair density [PMC7178635]. This suggests that it plays a role in determining hair density. Furthermore, ocu-mir-205 alters the expression of genes involved in the PI3K/Akt, Wnt, Notch, and BMP signaling pathways [PMC7178635]. Overall, ocu-mir-205 promotes apoptosis in DPCs and modulates the expression of genes and proteins involved in various signaling pathways to regulate hair follicle development and hair density [PMC7178635].