ssc-mir-205: Ssc-mir-205 is a microRNA that has been found to be upregulated in response to deoxynivalenol (DON) exposure in pigs [PMC8585098]. It is one of several microRNAs that showed increased abundance compared to previous time points, indicating a stronger effect of DON with longer periods of contaminated feed intake [PMC8585098]. Ssc-mir-205 was consistently upregulated in the jejunum of stressed pigs, suggesting its involvement in DON-induced effects [PMC8585098]. The upregulation of ssc-mir-205, along with ssc-miR-16, ssc-miR-128, and ssc-miR-451, was effective in distinguishing between DON-exposed and non-exposed pigs and could serve as candidate biomarkers for assessing the effects of DON [PMC8585098]. In vitro experiments showed that miR-205-5p (which has the same sequence as ssc-mir-205) suppressed the phosphorylation of p38 protein kinase and deactivated the MAPK and Wnt/β-catenin pathways, providing evidence for its involvement in DON-induced pathway suppression [PMC8585098]. Ssc-mir-205 has also been found to be upregulated in pig serum upon weaning stress and confirmed to be significantly upregulated upon DON treatment [PMC8585098]. The length of ssc-mir-205 varied from 18 to 23 nucleotides [PMC3901342]. Target prediction analysis revealed successful target gene prediction for 109 mRNAs associated with differentially expressed miRNAs including ssc-mir-205 [PMC9961432]. The mature miR-205 sequences were found to be highly conserved among pig, mouse, and human species [PMC7300349].