ccr-mir-29a: ccr-mir-29a is a microRNA that is potentially involved in regulating apoptosis [PMC4416013]. In the context of common carp, ccr-mir-29a and ccr-miR-143 have been identified as potential therapeutic biomarkers for remitting liver insulin resistance [PMC10113649]. It has been suggested that Momordica charantia saponins may have a role in alleviating liver insulin resistance by inhibiting ccr-mir-29a targeting pik3r1 or ccr-miR-143 targeting pik3r3 [PMC10113649]. In a study on common carp, the expression of ccr-mir-29a and ccr-miR-143 was found to be significantly downregulated in groups with liver insulin resistance compared to the control group [PMC10113649]. Additionally, 10 other differentially expressed microRNAs were identified as potential biomarkers for regulating insulin signal transduction and carbohydrate metabolism in the liver of common carp fed with a high-carbohydrate diet [PMC10113649]. These findings provide insights into the potential role of ccr-mir-29a and other microRNAs in modulating liver insulin resistance and suggest that Momordica charantia saponins may have therapeutic potential for improving insulin resistance in common carp [PMC10113649].