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mmu-mir-29c: Mmu-mir-29c is a member of the miR-29 family of miRNAs and is a putative target in various biological processes, including glucose homeostasis, myogenesis, and asthma progression [PMC3357342] [PMC3698551] [PMC5219731] [PMC3030602]. It has been observed that mmu-mir-29c interacts with MAX-like protein X (MLX) and glucagon (GCG) in the network, suggesting its involvement in glucose regulation [PMC3357342]. Mmu-mir-29c has been found to be downregulated in chronic lymphocytic leukemia patients with TP53 abnormalities and its expression has been shown to increase in glomeruli and microvascular endothelial cells in a mouse model [PMC3742134] [PMC8869454]. Overexpression of mmu-mir-29c has been associated with the activation of RhoA and suppression of Sprouty homolog 1 gene, which is implicated in diabetic nephropathy pathogenesis [PMC6032378]. Additionally, mmu-mir-29c has been linked to strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice [PMC3742134]. It is worth noting that mmu-mir-29c expression levels can vary with age, as it was found to be downregulated at intermediate and late stages of asthma progression but upregulated at the late stage along with other miRNAs such as mmu-miR-125b-5p and -574-5p [PMC3030602]. Overall, mmu-mir-29c plays a significant role in various biological processes and its dysregulation can have implications for disease pathogenesis.
mRNA interactions
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