ssc-mir-126: Ssc-mir-126 is a down-regulated miRNA that is significantly expressed less in HG- than in LG-IEN [PMC5707088]. It is also one of the selected genes containing differentially methylated regions (DMRs) adjacent to transcription start sites (TSSs) [PMC6014285]. Ssc-mir-126 has been validated by qRT-PCR and shown to be differentially expressed in breed groups [PMC4970254]. It is also involved in energy metabolism pathways and has been found to be differentially expressed in cancer pathways [PMC3555835]. Ssc-mir-126 and its counterpart ssc-mir-126* are transcribed together and have been found to be suggestively up-regulated in EA [PMC3555835]. The length of the ssc-mir-126 gene is 73 bp, and its mature sequence and seed region are consistent with those found in other vertebrates [PMC7080823]. The miRNA response elements (MREs) of ssc-mir-126 have been predicted using bioinformatics tools [PMC7080823]. Ssc-mir-126 is an intronic miRNA embedded within the introns of the gene encoding protein EGFL7 [PMC7080823]. References: [PMC5707088] [PMC6014285] [PMC4970254] [PMC3555835] [PMC7080823]