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mmu-mir-200a: mmu-mir-200a, a microRNA, is implicated in various stages of cellular processes, interacting with different genes such as MEIS1 in early stages and BRCA1 in later stages [PMC3866260]. It is one of five miRNAs that participate in both early and late cellular stages [PMC3866260]. This miRNA, along with mmu-mir-200b, is part of the miR-200b/200a/429 cluster and is potentially upregulated by transcription factors including Sox2 and Pou5f1 [PMC7906897]. However, mmu-mir-200a can be downregulated in white adipose tissue (WAT) as a response to high-fat diet (HFD) feeding [PMC4571067], which can facilitate the expression of PTEN, influencing cell proliferation and apoptosis during decidualization [PMC5699189]. Shen et al. reported that mmu-mir-200a plays a crucial role in embryonic implantation by targeting the phosphatase and tensin homolog gene [PMC5364990]. Moreover, knockdown experiments have shown that reducing mmu-mir-200a levels can lead to increased expression of Dcx and Map2 positive cells which are indicative of neurogenesis [PMC3679101]. This microRNA's expression levels are significantly decreased in neural stem cells (NSCs) from diabetic pregnancies compared to controls [PMC3679101], highlighting its role in neurogenesis regulation.
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