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Mus musculus (house mouse) mmu-miR-200a-3p URS000008DA94_10090

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mmu-mir-200a: Mmu-mir-200a is a microRNA that plays different roles in the early and late stages of development, depending on its interactions with MEIS1 and BRCA1 [PMC3866260]. It is one of the five miRNAs, along with mmu-mir-200b, mmu-mir-135b, mmu-mir-494, and mmu-mir-503, that participate in both the early and late stages [PMC3866260]. Mmu-mir-200a and mmu-miR-200b are part of the miR-200b/200a/429 cluster and can be up-regulated by Sox2, Pitx2, Pou5f1, and Hnf1b [PMC7906897]. In a microarray experiment involving high-fat diet feeding in mice, mmu-miR-141 and mmu-mir-200a were downregulated [PMC4571067]. Down-regulation of mmu-mir-200a facilitated the expression of PTEN during decidualization [PMC5699189]. Mmu-mir-200a has been found to have an important role in embryonic implantation by targeting phosphatase and tensin homolog [PMC5364990]. In NSCs from diabetic pregnancy mice, reduced expression of miRNAs including mmu-mir-200a correlated with increased protein expression of Dcx and Pafah1b1 [PMC3679101]. Knockdown experiments showed that downregulation of mmu-miR-141 or mmu-miR-466a resulted in increased expression of Dcx in NSCs [PMC3679101]. The expression levels of miRNA including mmu-mir-200a were significantly decreased in NSCs from diabetic pregnancy compared to control samples [PMC3679101]. Mmu mir 466d 3p was found to target Gfap protein during neurogenesis in vitro when knocked down along with other miRNAs including mir 200a [PMC3679101].

Genome locations

Gene Ontology annotations


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This sequence is found in 21 other species

  1. Alligator mississippiensis (American alligator) ami-miR-200a-3p
  2. Anolis carolinensis aca-miR-200a-3p
  3. Capra hircus (goat) miR-200a
  4. Chiloscyllium plagiosum microRNA cpl-miR-200a
  5. Danio rerio dre-miR-200a-3p
  6. Equus caballus eca-miR-200a
  7. Gadus morhua (Atlantic cod) gmo-miR-200a-3p
  8. Gallus gallus gga-miR-200a-3p
  9. Gorilla gorilla gorilla ggo-miR-200a (MIR200A)
  10. Gorilla gorilla ggo-miR-200a
  11. Homo sapiens hsa-miR-200a-3p
  12. Macaca mulatta mml-miR-200a-3p
  13. Monodelphis domestica mdo-miR-200a-3p
  14. Ovis aries (sheep) miscellaneous RNA
  15. Pan troglodytes (chimpanzee) ptr-miR-200a
  16. Pongo pygmaeus ppy-miR-200a
  17. Rattus norvegicus (Norway rat) rno-miR-200a-3p
  18. Takifugu rubripes fru-miR-200a
  19. Tetraodon nigroviridis (spotted green pufferfish) tni-miR-200a
  20. Tor tambroides miR-200a-3p
  21. Xenopus tropicalis (tropical clawed frog) xtr-miR-200a