bta-mir-486: Bta-mir-486 is a microRNA that has been found to be associated with skeletal muscle growth and downregulated in feed efficient animals [PMC6637853]. Functional enrichment analysis of bta-mir-486 and other microRNAs indicated that the insulin signaling pathway was over-represented in both tissues [PMC6244318]. In a reference Nelore population, bta-miR-423-5p and bta-mir-486 were differentially expressed between extreme groups for IMF31 and RFI66, respectively [PMC8016890]. Bta-mir-486 was identified as a top regulator for CLA content [PMC6637853]. In the development stages, bta-mir-486 was one of the top 20 most abundant microRNAs [PMC7073773]. Additionally, it was found that bta-miR-2285p, bta-miR-98, bta-miR-155, bta-miR-374b, and bta-mir-486 target transcripts involved in signaling pathways regulating pluripotency of stem cells, mTOR signaling, and FoxO signaling [PMC9581129]. In summary, bta-mir-486 is a microRNA associated with skeletal muscle growth and downregulated in feed efficient animals. It is involved in the insulin signaling pathway and has been identified as a top regulator for CLA content. Bta-miR-423-5p and bta-mir-486 are differentially expressed between extreme groups for IMF31 and RFI66. Bta-mir 486 is one of the most abundant microRNAs during development stages. It targets transcripts involved in pluripotency of stem cells, mTOR signaling, and FoxO signaling pathways.