oar-mir-148a: Oar-mir-148a is a highly expressed miRNA that has been shown to play important roles in regulating GnRH release [PMC6974689]. It is part of a network of miRNAs, including oar-miR-379-5p, oar-miR-495-3p, oar-miR-143, oar-miR-106b, and oar-miR-218a, that co-regulate thyrotropin-releasing hormone (TRH) in the hypothalamus [PMC9222358]. These miRNAs and TRH have been implicated in the release of GnRH [PMC9222358]. Oar-mir-148a is highly expressed in the ovaries of various animal species, including goats, pigs, mice, and cattle [PMC7971002]. It is also associated with cellular differentiation and development [PMC9205095]. Oar-mir-148a has been found to be differentially expressed between seronegative and infected sheep and may have implications for host-virus interactions [PMC6339376]. In sheep with adrenal gland tumors (MM sheep), oar-mir-148a is upregulated along with other miRNAs such as oar-let7i and oar-let7g [PMC9205095]. The upregulated expression of oar-mir-148a has been validated through qPCR experiments [PMC6339376]. Overall, Oar-mir-148a appears to be a highly expressed miRNA that plays important roles in regulating GnRH release as well as cellular differentiation and development. It may also have implications for host-virus interactions.