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gga-mir-148a: Gga-mir-148a is a chicken miRNA that is expressed at a high level in IAH30 cells, as well as in chicken hepatocytes and ovarian RNA libraries [PMC3743212] [PMC3526641] [PMC4326283]. It is one of the dominant miRNAs expressed in the chicken ovary and has been shown to play a role in cell proliferation, apoptosis, and ovarian steroidogenesis [PMC5940789]. Gga-mir-148a has also been found to be more abundant in the lean line of chickens compared to the fat line [PMC4326283]. It interacts with the SOCS3 gene and is involved in the response to Campylobacter jejuni inoculation [PMC7248314]. Additionally, gga-mir-148a displays increased H3K4me3 marks in infected birds from the resistant line at 10 dpi [PMC4404578]. The expression of gga-mir-148a has been confirmed through qRT-PCR analysis, which aligns with sequencing data [PMC4735322]. However, despite its high expression levels and potential roles in various biological processes, research on gga-mir-148a is still limited in chickens [PMC7769946]. Further investigation is needed to determine whether gga-mir-148a can reduce tumor incidence by inhibiting cell proliferation and cycle.
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