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Homo sapiens (human) TSIX transcript, XIST antisense RNA URS000025784F_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

TSIX: TSIX is a non-coding RNA that plays a crucial role in X-inactivation. It is involved in the repression of Xist, the master regulator of X-inactivation, through both indirect and direct mechanisms [PMC5064214]. TSIX is repressed by REX1 and YY1, which compete for binding sites in the F repeat region of Xist exon 1 [PMC5064214]. The transcription level of TSIX is repressed by Oct4 gene, leading to the activation of Xist and subsequent chromosome inactivation [PMC3347565]. TSIX also affects gene expression in other contexts, such as reducing type I collagen expression in SSc fibroblasts [PMC6595547]. The absence of SPEN prevents the silencing of TSIX, which acts as a brake on Xist transcription [PMC8636516]. TSIX is less conserved in humans compared to mice at the sequence level [PMC8775829]. It has been shown that TSIX regulates X chromosome inactivation through its association with CTCF sites at the Xist locus [PMC3091324]. The presence or absence of TSIX signals does not always indicate an active or reactivated state of the X chromosome [PMC6403393]. Methylation differences are not observed for mutant pSS1Δ2.7 with normal TSIX transcription and random X-inactivation observed in female heterozygotes [PMC2577046]. The expression patterns between TSIX and Xist are correlated with compaction levels within their embedding topologically associated domains (TADs) [PMC5346151].

Targeting miRNAs 17 total

According to LncBase, this RNA is targeted by the following miRNAs:

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset 

UAAAAAUGUAAAAGAUCAGCUGGGUGUGGUGGCUCACACCUGUAAUCCCAGCACUUUGGGAGGCUGAGGUGGGUGGAUCACGAGAUCAGGAAUUCAAGACCAGCGUGGCCAACAUGGUGAAACCCUGUCUCUACUAAAAAUACAAAAAUUAGCUGAGCAUGAUGGUGCACACUGUAAUCCCAGCUACUCAGCAGGCUGUGGCAGGAGAAUCACUUGAACCCAGGAGGUAGAGGUUGCAGUGAGCCGAGAUCGCGCCAGUGCACUCCAUCCUGGGCAACAGAACAAGACUCCAACUCGAAAAAAAAAUCAAUAAAAAUGUAAAAGAUCAUUCUUAGCUUGGAGGCUAUAAAAAAGGAUGCAGCAUGUCAGAUUUGGCCCAUUAGCUGCAGUUUCCUGACCUCUAUCUACCUCAAUUGGUUCUUUACUUACAUUACAUGGAAAGUGCAAACUUGGAUGGCUUCAAUGUCUGGCUUCUUUUAUUUAUUUAUUUAUUUAUUUAUUUAUUUAUUUAUUUAUUUUUUGAGACGGGGUCUCGCUGUGGCCCGGGCUGGAGUGCAGUGGCACGAUCUCUGCUCACUGCAAGCUCCACCUCCUGGGUUCACACCAUUCUCCUGCCUCAGCCUCCCGAAUAGCUGGAACUACAGGUGCACGCCACCACGCUUGGCUAAUUUUUUAUAUUUUUAGUAGAGACGGGGUUUCACUGUGUUAGUUAGCCAGGAUGGUCUCGAUCUCCUGACCUCAUGAUCCGCCCAUCUCGGCCUCCCAAAGUGCUGGGAUUACAGGUGUGAGCCACCGUGCCCGGCUGGCUGGCUUCUUUUUACCCUUCACAUCUGGCUUUAAAUACUACCUUUUCACAGAUUUCUUCUCUAAUCACUCUUUCUAAAGUAAAUAUGCUGUUUUUCAUUAUUAGUCAUUGCAUCCUAUUUCUUUCCCUUUAAUUUUCUUAUCACAAUGUAUAAUUAUAUGUUUUUUUUUUUUUUUGGUUAUUGCCUGUCUCCCUCAAUAGAUCAUAAGUUCCAUUUGAUAAGGUACAAUGUCUGUUGGUUUAUUAGCCAGUGCCUAACACUACCAUUUAAUAUGUAUUCAAUGAAUAUUUGUUAAAUGUAUUGAUUGAAUUUAAAGUGACUACUCAGCCUACUUCUGCCCCUUGGAGCUUGGAUUGUUUCUUCAAAGGUAUUGAUCCUUUUGACUAUUUUAAUUAUGAAUUCACUAAAGACAUCUGGAAGGCUUAUUGUGUCAAGCAGUGCCAAAUCCAUGGCUUGAUGAACCUAGAUCCAUCCCCUUCCCCUUUCCAUAUCACAGAUGACAACUUGAUGGUUGGCCUAUGACUUGUAAAAGUUGUCAUAUUUGAAUUCUGAAAUUUCUCUAAUUUUCUUGGGAAGCAGAAAGGAAAAAUUAGUAGUUGGCCUCAAAGGGACAGUUGAAUUUCACAUAUAAUGAGCAAAGUAGUGUGAGGAAGAGAGGAGGGCCUUUUCUUUUGAGGUCAUAACUAAAAGUUAGGUGAGCAAAUGCCAUAAGCAUGAAAAUAGCAAACCAAGCUUCUUGGUUUCUAUCCAAAGGCUUUGUUGGGAAAAGUAUCAAAGUGUGUUCAUUUGUUAUGUAAUAUAUAAGGUAGAGAACCCAAUUUGAAGGAGGUGGAAUAACUUUCCAAAAUACUUAUGGCUAAAUUCUCAGUUGAUCUUGGAAUAAGAUUCAAGAAUCCAAAUGCACCCUUCUUUGUUAUCUUGCUAGAAAACAUGCUGGGCAUGGUGGCUCAUGCCUGUAAUCCCAACACGUUGAGAGGCCGAGGUGGGCAGAUCACGAGAUCAGGAGUUGGAGACCAGCCUGAUCAACAUGGUGAAGCCCCGUCUCUACUAAAAAUACAAAAAUUAGCCAGACAUAGUGGCACGCACCUAUAAUCCGUGCUACUCAGGAGGUAGGCAGGAGAAUUGCUGGAACCCGGGAGGUGGAGUUUGCAGUGAGCCAAGAUCACACCACUGCAAUCCAGCCUGGGUGACAGAGCGAGACUCUGUCUCAAAAAAAAAAGAAAAGAAAAAAGAAAAGAAAGAAAAAAGGGAAGGGAAGGAAAGGGGGGAGGGGAGGGAAGGGAAGGGAAGGGAAGGUAAGGGAAGGGAAGGGAAGGGAAGGGAAAAGGGAAAACAAUGUGCUUUUACCCACAGCUGAUAAGCUUUUCUAAUUGUCUACCUUUGGGUUAAACUUUAUCAUUGAGUGUUUUUAUCCCAUUAUGAAAGAAUUAAGGUUUGAAGGACUGAGGUAAGGGUGGAUAUUUACUCUUAAUUGAGUAGCUUAACCAAGUCAAGCCACAGAUUAGCUGAAGCCAAAAAGCACUGGCAGCAUUUGAAAUAACUGAGAACAUAUUAUACUUAACACUUUAUUAUCUAAGAGAGGCACUUGAAGUUGAGACCUAGAAAUUUGAUUCUGGGUUCUUUGUUUCUAAGGGGCAGGGUGAACCCAGCUAUAGCAUUCACAGAUGCUAUAGAAUUAUAUAUAUUCUAUAUAUAAUUAUAUAUAUUACAUUCAUAUUAAUAUAUGUUAAUAUAUUCUAUAUUAUUCAUAUAGAAUUCACAGAUAAUCCAAGUGCUUUUUUAAUACAUUGAUACCAAAUCUCUCCUGCUCUCAAAAAAAAAAGCCCAAGGCAAAAAUUUUUGAUUAGCCUGUAUCCGCAAAUUCAUAGUGCAUGGCAUGAUGGGUACUCUACAUCCCUCCUCCUAUUGCACUCACUGUGCCCAGAUGAACCUAAAGUCACCAGUAAUAGUGCUAAUGUAGUAAUGGGCCCAAGCUUCAAAAGAAGGAAAAUUAGUAUUCAGUAUUUAAAUGUGGGAAAGAGGAAGAAUAUGGAAAUUAUCAAUUUUAUAAUACCUAUACAUAUUCUUACCUGCAUUAAUGUGAAUAGACAUCAAUGAUAAACAGAAUAAUGCCCCAUAAAGAUGUCUACACUGUAAUCUCCAAAACUUAUAACUAUACUAUAUCACAUGGCAAGAGGGAAUUAAGGUUACUAAUCAGCUGACCUUGAGAUGGGAGAUUCUCCUGGUUUGUAUGGGUGGGCCCAAUGUAAUCACAGGGUCCUUAUAAAUGGAAAAGGCAGACAGGAGAUUCAGUGUCAGACUGAUACAAUGAGGGAAAGACUACCAGCAGUUGAUGGCUUUGAAGAUAGAAGAAGGGGGCCAUGAGCCAAGAAAUGUGAGUAGCCUCUAGAAGCUGAAAAAGGCAAGAAAACGGAUUCUUCCCUAGAAUCUCCAGAAAUGCAGCCCUGCCAACAUGGUGAUUUUAACUCAAUGAGAUGCAUUUUAGACUUCUGACAUCUAGAAUUGUGUUAUUUUCAGCCCUCAAGUUUGUGGUAAUUUGUUACAGCAGCAUUAAGAAAAUGUACAAUGACCAUGUGCAGUGCCUCAUGCUUGUAAUCCCAGCACUUUGGGAGGCCAAGGUGGGUGGAUCGCUUGAGUCCAAGAGUUCGAGACCAGCCUGGGAAACAUGGUGAAACCUUGUCUCUACAAAAACACAAAAAUUAGCCUGGUGUGGUUGUGUGGACCUGUAGUCCCAGCUACUCUGGAGGCUGAGGUGGGAGGAUGGCUUAAACCCAUAAGGUGGAGAUUACAAUGAGCCAAGAUCAUGCCACUGCACUCCAGCCUGGACAGUAGAGCCAGAACUUCUCUCAAAAAAAUAAAAAAGAAAGAAACUAUACAAUGCUCCUGUGAUUCUAGUGCUAUGUACAUAUAUCCUUUAUAGGGAAUUAAGGAGGUUAUAGACACAACCAGAAGAGGAGGCAUGGAAUAGACUAAUGUAUAAUGGAUAGGAAAGUGUAUCUUUUACAACUUCUCUGUAAAAACACCUUCACCUACUUUAUGAGUUUGCCUCAGCUGCCAUAACAAAAUAUCAGACCAAGUGGCUUAAAUAACAAUUUAUUUUCUCACAGUUCUGGAGGCUAGAAGUCUAAGAUGAAAGUGCCAGCAAGUUUGAUUUCUGGUGAAGUCUCUCUUCCUUGCUUGCCAAUGGCCGCUUUCUCACUGUGUCUUCAAAUGUCCUUCCUCUGAGUAUGUGAGGAGAGAGAGGUUUGAUGCCUCUUCACCUUCUUAUAAGGACACCAGUCCUACUGGAUUAGGGCUCCACCCUUAUGACCUCAUUUAACCUUAAUUACCUCCUUAAAGGUUCUAUCUCCAAAUACAGUCACAUUUGGAGUCAGACCUACAACAUAUGAAUUUUGAGAGGACACAAUUCAGUCUAUAACACCUAGAUGGAAGGCAAUUUCAUAUAAAGAUGAUAUGCAGUCUAUGACAGCAAAGUAGCUAGUGGAAAUCACAACCCCUAAUUCUAUUUUUAUGUCAUUCCCUAAGUCCAGGUCCCAUGUGGAUAUAGCAUUGUUCAGGGCUAUCUCUUUGCUGUUCUUUUUUUUUUUUUAGACUCACACAAGCAAUGUGGAGAAGGAACAUGAAAACAUCUUUGAGAUAGAGCUUAAUACAGAUGUCAAUCUCUUUGUAAAUAAGCAAUUAAAAGUGGAACCACUGUCCACCAUGUGAGAAGAGUGACUGGCUAUGGCUGGAUAUUUUUAAAUACACAUAAAAUGUGGUAUAAAUGGUAGAAUGCCAGGGAUAGAAGGAGUAUCUUAUAAGUUACCUAGUCAACGUUCUGGCUUCUGGGCAGAAAACUAUCUAAACUCAGCCAGAUAAUCAGUUUCAACUAAAUCAGGAAAACAUGGAAUCAUCUUUAUCUAGGUAGUGUUAUAGUUACAUUGCCUCAUUUAUCUACACAUCAAUAAAUUCUUUCUCAUUGCUAAUAUUUAUCAUUCUUAUCAUAGUAUAAGCAAAUGUUUUAAUUCUAUUAUGGUAAAGAUAAAGCUUCUGUAAUUAAAACACUUUAAUCUGGAAAGACAGCAGUAAACCCUUCAAGCAAAAGCCCAAGUAGGUUCAAAAAUAAUAGCCAGAGAGGUUAAAGGUAAACCAAUAGAGUGAUAUGUUACAGCAACUAAGGGAGAGAGGCAGGAGUUUUUUAAAAGAGAGAAGAGG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Taxonomic tree

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