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bta-mir-432: Bta-mir-432 is a microRNA that has been found to have higher expression levels in mature testicular tissue [PMC8614260]. It has been shown to target ACTG1 and potentially activate the IGF2/AKT signaling pathway, promoting the proliferation and differentiation of myoblasts [PMC8759604]. Bta-mir-432 is differentially expressed in serum after MAP infection, with a 2-fold upregulation before infection and a 2-fold downregulation after 6 months of infection [PMC6600136] [PMC7242893]. It targets the RTL1 gene along with other miRNAs such as bta-miR-136, bta-miR-127, bta-miR-433, and bta-miR-431 [PMC8787201]. Bta-mir-432 has identical binding positions to hsa-miR-432 in the human RTL1 gene [PMC8787201]. It has also been found in bovine milk and colostrum along with other miRNAs such as bta-miR-135a, bta-miR-136, bta-miR-127, bta-miR431, and bta-mir433 [PMC8787201]. Bovine miRNAs including bta-mir432 have identical counterparts in humans as well [PMC8787201]. Bovine miRNAs including bta mir432 have binding sites that are fully complementary to human gene mRNAs [PMC8787201]. Additionally, it is found in a novel circular RNA along with other miRNAs such as let7a5p and let7e among others [PMC7230347]. BtamiRNA432 was initially identified through computer analysis of other animal sequences by Artzi et al. in 2008. In the AF library, bta-mir-432 had a high number of reads compared to the AM library [PMC4090223]. It is associated with GO terms related to lipid metabolism and adipogenesis [PMC4090223].
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