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oar-mir-432: Oar-mir-432 is a microRNA that has been found to have a positive correlation with KRT83, indicating a potential interaction between the two [PMC5948824]. The target mRNAs of oar-mir-432 were predicted using three different predictive software, namely RNAhybrid, TargetScan, and miRanda algorithm [PMC9087340]. The seed motif of oar-mir-432 was found to be mutated at the 3'-UTR site of BMP2 [PMC9087340]. In an experiment with preadipocytes, oar-mir-432 was transfected and resulted in downregulated expression levels of the marker gene PPAR-γ during adipogenesis [PMC9087340]. The expression trends of oar-mir-432 and SIRT1 were found to be contrasting at the RNA level [PMC10035661]. Additionally, both oar-mir-432 and KRT83 showed lower expression levels in adult compared to lamb [PMC5948824]. Furthermore, the expression of SIRT1 was inhibited by oar-mir-432 mimics as observed in Western blot analysis [PMC10035661].
References:
[PMC5948824] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948824/
[PMC9087340] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087340/
[John et al., 2004] - https://pubmed.ncbi.nlm.nih.gov/15215398/
[Krüger and Rehmsmeier, 2006] - https://pubmed.ncbi.nlm.nih.gov/16787918/
[Agarwal et al., 2015] - https://pubmed.ncbi.nlm.nih.gov/25409818/
[PMC10035661] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035661/
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