mmu-mir-375: Mmu-mir-375 is a microRNA that has been studied in various contexts. It has been reported that Tan IIA downregulates mmu-mir-375 to increase the KLF4 protein expression and ameliorate atherosclerosis in ApoE knockout mice [PMC9273410]. Mmu-mir-375 does not affect the secondary signals or the actin filament network [PMC1790902]. It is suspected to play a role in exocytosis processes [PMC1790902]. Mtpn has been validated as a target gene of mmu-mir-375 [PMC1790902]. The expression of mmu-mir-375 is limited to pancreatic β cells, but it has also been detected in the rat lung [PMC1790902]. Mmu-mir-375 is highly expressed in the lung and has an identical mature sequence between human and mouse, but it targets different genes between the two species [PMC5372489]. It is upregulated in prostate cancer and hepatocellular carcinoma, but decreased in squamous cell carcinoma [PMC8287301]. In mouse OIR retinas, mmu-mir-375 showed significant down-regulation [PMC5032015]. Mmu-miR-7-5p and mmu-miR-26a-5p are more abundant than mmu-mir-375 in MIN6 cells, while the opposite is observed in murine acini cells [PMC10037588]. The targets of mmu-mir-375 are limited according to available databases, with only 20 experimentally confirmed targets expressed in heart tissue [PMC7765785]. Mmu-miR-141, mmu-miR298, and mmu-miR 346 levels are altered with disease progression and released into serum samples. In MIN6 cells, transfection with different mimics or inhibitors of mmu-mir-375 and mmu-miR-29 showed varying effects [PMC3767796]. These findings highlight the diverse roles and expression patterns of mmu-mir-375 in different biological contexts.