cfa-mir-375: Cfa-mir-375 is a microRNA that has been studied in relation to various heart diseases in dogs. It has been found to have moderate inverse correlations with plasma PIIINP concentration, along with other microRNAs such as cfa-miR-885, cfa-miR-211, cfa-miR-200c*, and cfa-miR-182 [PMC3668254]. In dogs with mitral valve disease (MMVD), cfa-mir-375 was significantly down-regulated compared to healthy dogs [PMC8062772]. It was also found to be upregulated in both eccentric and concentric cardiac hypertrophy groups, with a higher fold change in the concentric hypertrophy group [PMC8542680]. Cfa-mir-375 was identified as an accurate indicator associated with concentric cardiac hypertrophy [PMC8542680]. It showed significant positive correlations with left ventricular (LV) concentric hypertrophy indices such as left ventricular posterior wall thickness during diastole normalized (LVPWdN) and relative wall thickness (RWT) [PMC8542680]. Cfa-mir-375, along with cfa-let-7b, was able to distinguish dogs with concentric hypertrophy from those without it [PMC8542680]. However, the specificity of cfa-mir-375 for concentric cardiac hypertrophy was higher compared to that of cfa-let7b [PMC8542680]. Further research is needed to understand the expression and specific role of cfa-mir-375 in different types of cardiac hypertrophy in dogs [PMC8542680].