bta-mir-183: Bta-mir-183 is a microRNA that negatively regulates the expression of CFL2 [PMC9774386]. It can be mimicked or inhibited using products from GenePharma [PMC9774386]. Bta-mir-183 has been shown to be a regulator of proteolysis in muscle, which affects meat tenderness [PMC9774386]. In C2C12 cell lines, treating with bta-mir-183 mimic or inhibitor resulted in statistically induced or suppressed mRNA levels [PMC9774386]. In silico analysis revealed highly conservative bta-mir-183 target sites in the 3′UTR of CFL2 mRNA across different species [PMC9774386]. Bta-mir-183 directly targets and regulates CFL2 expression, as shown by luciferase reporter assays and mRNA and protein level analysis [PMC9774386]. Bta-mir-183 can suppress PBM differentiation and downregulate the mRNA levels of myoblast differentiation marker genes MYOD, MYOG, and MYH3 [PMC9774386]. It can also downregulate 8 different genes to influence protein yield [PMC6164576]. Bta-mir-183 is one of the miRNAs that negatively correlates with candidate genes for protein yield, milk yield, and C17:0 fatty acid content [PMC6164576]. It is upregulated in the L group compared to the H group and may downregulate the target gene GCLM involved in glutathione synthesis [PMC6317189]. Bta-miR-196a, bta-miR-182, bta-mir-183, and bta-miR-96 are significantly higher expressed in yak testes during development compared to other miRNAs studied [PMC9940382]. Bta-mir-182, bta-miR-96, and bta-mir-183 are members of the miR-183 cluster and are highly enriched in preovulatory dominant follicles [PMC4438052]. Bta-mir-182, bta-mir-183, and bta-mir-338 regulate the expression levels of genes associated with several pathways [PMC7140828]. The expression level of bta-mir-183 is decreased in SF groups [PMC4156418].