bmo-mir-275: Bmo-mir-275 is a microRNA that belongs to the mir-275 family [PMC2435238]. It has been found to have higher read counts compared to bmo-miR-305 in the anterior-middle and posterior silk gland, but only two-fold greater relative to the whole body [PMC2838851]. Previous studies have shown that bmo-mir-275 has negative effects on the expression of SGF1 and BmSer-2, with SGF1 being an important transcription factor regulating the expression of FibH, Ser-1, and P25 [PMC7859555]. In a study analyzing the expression patterns of nearly 100 miRNAs in multiple tissues of B. mori, bmo-mir-275 was found to be distributed exclusively or preferentially in specific tissues such as the silk gland [PMC4222307]. It was also found that bmo-mir-275 has nucleotide differences in its sequence compared to its predicted sequence or homologs in closely related species [PMC2500172]. Furthermore, bioinformatics analysis has predicted BmSer-2 as a potential target gene for bmo-mir-275 [PMC5790233]. The expression of bmo-mir-275 and its target gene BmSer-2 was found to be highly tissue-specific in fifth instar 3-day larvae [PMC5790233]. Additionally, it has been shown that bmo-mir-275 is up-regulated during metamorphosis and during infection of the midgut [PMC3699532]. References: [PMC2435238] [PMC2838851] [PMC7859555] [PMC4222307] [PMC2500172] [PMC5790233] [PM3699532]