bma-let-7: bma-let-7 is a mature miRNA found in Brugia malayi, a parasitic nematode. It shares perfect sequence identity with mature miRNAs in Homo sapiens [PMC4581865]. It is significantly enriched in L3 extracellular vesicles (ELVs) compared to L3 tissue [PMC4581865]. The presence of bma-let-7 and other parasite miRNAs with high homology to host miRNAs suggests a potential ELV-mediated mechanism for parasite RNA to influence gene expression in host cells [PMC4581865]. The expression of bma-let-7 and other miRNAs varies between male and female parasites, with the bma-let-7 family, bma-miR-283, bma-miR-2e, bma-miR-57, and bam-miR-5838 being more abundant in males, while bma-miR2b-* and the bma-miR36 family are more highly expressed in females [PMC9861972]. Several of these miRNAs have immunomodulatory properties by downregulating proteins involved in the mTOR pathway [PMC9861972]. It has been suggested that vesicles containing these miRNAs regulate the host immune response through an miRNA-dependent pathway [PMC6340962]. In particular, bma-let-7 has been shown to modulate the vertebrate immune response [PMC6340962]. Researchers have found increased expression of bma-let7 along with other specific miRNAs when comparing their expression levels [PMC6340962].