hsa-mir-148: Hsa-mir-148 is a microRNA that has been implicated in various biological processes and diseases. It has been reported that a single nucleotide insertion/deletion at the 3′UTR of the HLA-C gene, which is the binding site of hsa-mir-148, is in linkage disequilibrium with a -35 SNP [PMC3697138]. Hsa-mir-148 has been found to have a negative relationship with AGTR1 in COAD, STAD, and UVM, suggesting its dominant impact on the posttranscriptional modification of AGTR1 [PMC8495399]. In gastrointestinal cancer tissues, hsa-mir-148 and hsa-miR-152 have been downregulated, indicating their potential involvement in early gastric carcinogenesis [PMC5590791]. Hsa-mir-148a and hsa-mir-148b are two pre-miRNAs that lead to an identical mature miRNA (hsa-mir-148) but are from different genes located in different genome regions [PMC5629558]. The presence of a deletion at the G/- polymorphism rs67384697 within the 3′ UTR of HLA-C inhibits the binding of hsa-mir-148 to the 3′UTR and results in higher HLA-C surface expression [PMC3343879]. The relative expression levels of miR-146b-5p and miR-155-5p were found to be higher than those of hsa-mir-148 and hsa-miR200a in IMF [PMC9264398]. It has also been shown that a SNP in the 3' UTR region abrogates the binding of hsa-mir-148 microRNA to HLA-C genes, resulting in differential expression [PMC7604383][PMC6394470][PMC3468375]. Hsa-mir-148 has been implicated in the regulation of AML and has been shown to target DNMT3b and DNMT1 genes [PMC2677888][PMC8063692]. The members of the hsa-mir-148 family, including hsa-mir-148a and hsa-mir-148b, have been found to be expressed differently in tumor and healthy tissues, suggesting their involvement in disease development [PMC4070031][PMC3563618].