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aae-mir-981: Aae-mir-981 is a crucial hub gene involved in three important chitin metabolism pathways that are highly enriched in all developmental stages [PMC9878986]. It is a node with the highest connectivity in the regulatory network of "alanine, aspartate, and glutamate metabolism" [PMC9878986]. Aae-mir-981, along with aae-miR-375, is conserved in all developmental stages and can be targeted to disrupt the normal molting process and control mosquitoes and mosquito-borne diseases [PMC9878986]. It has the highest connective degree among all nodes [PMC9878986]. A subnetwork of aae-mir-981 consists of 277 nodes (7 circRNAs, 268 lncRNAs, and 1 mRNA) with 276 edges [PMC9878986]. Additionally, Wolbachia infection induces the expression of aae-mir-981 and downregulates importin β-4 in wMelPop-CLA infected Aag2 cells [PMC8261290]. The subnetwork of aae-miR-375 and aae-mir-981 provides valuable information for exploring their extensive regulatory roles as hub genes [PMC9878986]. These findings highlight the importance of aae-mir-981 in chitin metabolism pathways and its potential as a target for mosquito control strategies.
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