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cfa-mir-206: Cfa-mir-206 is a highly expressed miRNA in skeletal muscle [PMC4989286]. It is one of the 5 TE miRNAs found in both the dog heart and skeletal muscle [PMC4989286]. Transient elevations of cfa-mir-206 in the serum were observed, but they were not correlated with any microscopic findings and may be due to injury during animal handling [PMC4989286]. Cfa-mir-206 was included in a panel of miRNAs evaluated for heart, muscle, brain, sciatic nerve, testis, pancreas, and liver tissues [PMC4989286]. It was also selected as one of the 22 miRNAs for qPCR validation as a biomarker candidate for muscle toxicity [PMC4989286]. Downregulation of cfa-mir-206 was observed at 36 dpi and was associated with an attenuated inflammatory response by targeting tcf7l2 [PMC9558963]. Tcf7l2 is a potential target gene of cfa-mir-206 and is involved in various cellular processes such as cell-cell signaling and regulation of response to stimulus [PMC9558963]. Cfa-mir-206 has also been implicated in canine atrial fibrillation, with increased expression observed during atrial fibrillation induced by right atrial tachypacing [PMC4490541] [PMC5533140].
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