rno-mir-206: rno-mir-206 is a muscle-specific miRNA that plays a crucial role in muscle cell proliferation, differentiation, apoptosis, migration, and angiogenesis [PMC5270432]. Increased expression levels of rno-mir-206 in cerebral ischemia have been associated with the progression of injury [PMC5270432]. However, marginal downregulation of rno-mir-206 and rno-miR-494-3p at 6 hours post ischemia may contribute to the promotion of recovery [PMC5270432]. In a rat model of cerebral ischemia, underexpression of rno-mir-206 at 72 hours post MCAO was observed, leading to neurogenesis and explaining the spontaneous recovery observed in the rat model [PMC5270432]. Overexpression of rno-mir-206 was found to inhibit neural cell viability [PMC5270432]. Other miRNAs such as miR-214, miR-223, miR-298, miR-327, and miR-494 have also been reported to be overexpressed during ischemia/reperfusion periods in rat models [PMC7555634]. Expression levels of rno-mir-206 correlated well with infarct volumes in a rat model with high R values [PMC3688919]. Expression levels of rno-mir-206 increased from 0 hrs to 24 hrs and gradually decreased from 48 hrs to 168 hrs post-ischemia/reperfusion [PMC3688919]. Rno-mir-206 is known to be abundant in muscle tissue but has also been reported in the rat hippocampus and striatum [PMC9833481]. Additionally, rno-miR-183/96, rno-miR30b,rn0o-rmi-R150,andrnomi-Rn6o-were foundtodysregulatedin two or more studies, suggesting that various factors could influence miRNA expression [PMC10045079].
Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset
View annotations in different species by clicking on species names.
Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.