rno-mir-206: rno-mir-206 is a muscle-specific miRNA that plays a crucial role in muscle cell proliferation, differentiation, apoptosis, migration, and angiogenesis [PMC5270432]. Increased expression levels of rno-mir-206 in cerebral ischemia have been associated with the progression of injury [PMC5270432]. However, marginal downregulation of rno-mir-206 and rno-miR-494-3p at 6 hours post ischemia may contribute to the promotion of recovery [PMC5270432]. In a rat model of cerebral ischemia, underexpression of rno-mir-206 at 72 hours post MCAO was observed, leading to neurogenesis and explaining the spontaneous recovery observed in the rat model [PMC5270432]. Overexpression of rno-mir-206 was found to inhibit neural cell viability [PMC5270432]. Other miRNAs such as miR-214, miR-223, miR-298, miR-327, and miR-494 have also been reported to be overexpressed during ischemia/reperfusion periods in rat models [PMC7555634]. Expression levels of rno-mir-206 correlated well with infarct volumes in a rat model with high R values [PMC3688919]. Expression levels of rno-mir-206 increased from 0 hrs to 24 hrs and gradually decreased from 48 hrs to 168 hrs post-ischemia/reperfusion [PMC3688919]. Rno-mir-206 is known to be abundant in muscle tissue but has also been reported in the rat hippocampus and striatum [PMC9833481]. Additionally, rno-miR-183/96, rno-miR30b,rn0o-rmi-R150,andrnomi-Rn6o-were foundtodysregulatedin two or more studies, suggesting that various factors could influence miRNA expression [PMC10045079].