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cfa-mir-122: Cfa-mir-122 is an up-regulated microRNA that can down-regulate epo, leading to anemia symptoms in puppies [PMC9773451]. In a study, four differentially expressed microRNAs, including cfa-mir-122 and cfa-miR-193b, were found to potentially regulate 48 target genes [PMC9773451]. Cfa-mir-122 is considered highly liver-enriched and can serve as a biomarker for liver function [PMC4989286]. Other miRNAs evaluated in the study include cfa-miR-885, cfa-miR-1, cfa-miR-133, cfa-miR-206, cfa-miR-34b/c, and cfa-miR-212 [PMC4989286]. Cfa-mir-122 showed high diagnostic performance for early diagnosis of mild hepatic steatosis in dogs with splenoazygos or splenophrenic groups compared to other biochemical parameters such as ALT [PMC7356535]. In differentiating splenocaval shunts from healthy controls, serum levels of miRNAs including cfa-mir-122 showed high sensitivity and specificity with an AUC of 0.99 [PMC7356535]. CFA mir 122 was significantly upregulated in all CPSS groups compared to the control group with high sensitivity and specificity according to AUC yield in each group [PMC7356535]. In discriminating right or left divisional IHPSS group from the control group, miRNA such as CFA mir 126 showed higher diagnostic performance than cfa-mir-122 [PMC7356535]. Seventeen differentially expressed mature miRNAs, including cfa-mir-122, were validated by qRT-PCR in a miRNA-mRNA interaction network [PMC5844969].
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