dre-mir-122: Dre-miR-122 is a microRNA (miRNA) that is specifically associated with the liver in zebrafish, as demonstrated by its down-regulated transcription levels in the liver following microcystin (MC) exposure [PMC5308255]. This miRNA is also notably enriched in the ovaries compared to the testes, suggesting a differential expression based on sex [PMC9495813]. Upon stimulation with lipopolysaccharide (LPS), dre-miR-122 expression levels were found to be upregulated, indicating its potential involvement in immune or inflammatory responses [PMC8268205]. In the context of infection by A. salmonicida in S. maximus spleen, dre-miR-122 was among the differentially expressed miRNAs that were measured [PMC8301059]. Additionally, exposure to bisphenol A (BPA) resulted in a significant upregulation of dre-miR-122 specifically in adult male zebrafish liver, suggesting its responsiveness to environmental contaminants [PMC5664119]. In transgenic zebrafish overexpressing gankyrin, an increase in dre-miR-122 was associated with altered metabolic and apoptotic processes within the liver [PMC5664119]. Lastly, while other miRNAs such as dre-miR-103 are found both in gut and liver tissues, dre-mir-122 expression is exclusive to the liver [PMC2684549], reinforcing its role as a hepatic-specific miRNA.