eca-mir-215: Eca-mir-215 is a miRNA that has been identified as a statistically significant differentially expressed miRNA (DEmiR) in multiple studies. Using DESeq2, 11 DEmiRs were identified, including eca-mir-215, in a study that accounted for the level of hemolysis [PMC5748701]. Eight of these DEmiRs were also reported by edgeR [PMC5748701]. In an equine model of severe asthma, eca-mir-215 was found to be differentially expressed in serum and was shown to regulate airway remodeling and CD4+ T cell maturation and differentiation [PMC8372030]. Eca-mir-215 was also identified as a DEmiR in plasma and synovial fluid (SF)-derived extracellular vesicles (EVs) in the context of osteochondral injury [PMC9393553]. Additionally, eca-mir-215 was found to be differentially expressed in plasma and SF when comparing control samples to osteoarthritis samples or samples at different time points [PMC9393553]. Eca-mir-215 was also identified as a DEmiR in pairwise comparisons between control and osteoarthritis samples [PMC9393553]. Overall, these studies highlight the potential role of eca-mir-215 in various biological processes and its relevance as a potential biomarker or therapeutic target.