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hsa-mir-202: Hsa-mir-202 is a microRNA that has been studied in various contexts [PMC5768793]. Pemetrexed treatment was found to increase the expression levels of MTHFD2 while decreasing the levels of hsa-mir-202 in multiple cell lines [PMC5768793]. The T allele of SNP rs12355840 in hsa-mir-202 was found to have a higher frequency in non-African populations compared to African populations and has been associated with breast cancer mortality [PMC8395730]. Hsa-mir-202 was also found to be correlated with esophageal cancer [PMC4143210]. Tissue-specific expression analysis showed that hsa-mir-202 is more highly expressed in prostate cells compared to breast or ovarian tissues [PMC4159108]. Leukorrhea-derived exosomal hsa-mir-202 has the potential to be used as a non-invasive biomarker for the diagnosis of endometriosis-associated infertility [PMC9830089]. Differential expression analysis identified hsa-mir-202 as one of the downregulated miRNAs in a study on endometriosis-associated infertility [PMC7657683]. In ERBB2 overexpressing cell lines, hsa-mir-202 was found to be more highly expressed in luminal cell lines lacking ERBB2 overexpression compared to luminal cell lines with ERBB2 overexpression [PMC3672661]. Hsa-miR-let7 family, hsa-miR-15a, and other miRNAs were identified as having overlapping mRNA targets with hsa-mir-202 [PMC3424689].
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