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bta-mir-214: Bta-mir-214 is a microRNA that has been identified in various studies to be differentially expressed in different biological contexts. It has been found to be highly enriched in the follicular fluid of subordinate follicles compared to dominant follicles [PMC4438052]. Bta-mir-214, along with other miRNAs, has also been identified as a regulator of inflammation in bovine mammary epithelial cells [PMC5821052]. It is expressed at a higher level in the fetal bovine ovary compared to somatic tissue pools [PMC4522283]. Bta-mir-214 has been implicated in regulating the NF-kappa B signaling pathway [PMC6600136]. Additionally, it has been found to be enriched in the secretory fluid of the estrous cycle at day 3 but repressed at day 7 compared to dominant follicle groups [PMC4156418]. Bta-mir-214 is also differentially expressed during lactation, with higher expression levels observed during late lactation compared to peak lactation [PMC3498112]. It targets various genes, including IRF1, and is predicted to regulate multiple target genes [PMC7554596] [PMC3596360]. Furthermore, bta-mir-214 is part of a miRNA-mRNA network that regulates key signal transduction pathways associated with energy homeostasis and immune response in transition dairy cows [PMC9445238]. However, its specific role and targets are still not fully understood.
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