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gga-mir-214: Gga-mir-214 is a microRNA that has been extensively studied in various contexts [PMC9188098]. It has been found to regulate the greatest number of target genes among differentially expressed microRNAs (DEMs), with 5 targets [PMC9188098]. In a study on the KO-IFNAR1 group, gga-mir-214 was found to be one of the eight most significantly down-regulated genes [PMC9611459]. It has also been identified as one of the upregulated miRNAs in LB strain, showing enrichment with its target genes [PMC8241840]. Furthermore, gga-mir-214 was found to be significantly up-regulated in chicken thymus under immunosuppressive conditions [PMC7894119]. In another study, gga-mir-214 was chosen as one of the DEMs to validate its expression trend using qPCR [PMC8633681]. Additionally, gga-mir-214 was found to be up-regulated in infected samples compared to control samples [PMC7931527]. The expression levels of gga-mir-214 were also evaluated in resistant and susceptible chickens, showing higher levels in resistant chickens [PMC7931527]. Moreover, gga-mir-214 has been identified as one of the miRNAs targeting key gene TGFB3 in various signaling pathways [PMC6815035]. It has also been found to interact with other genes involved in different pathways such as ABC transporters and PPAR pathway [PMC5788541]. Finally, gga-mir-214 was significantly expressed in both abdominal preadipocytes and differentiated adipocytes but at different rates compared to other miRNAs studied [PMC8002044].
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