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ssc-mir-214: Ssc-mir-214 is a microRNA that has been found to be up-regulated in ER compared to LL sows and is involved in promoting apoptosis and suppressing cell proliferation in various cell types [PMC6677090]. It has been identified as a homolog of hsa-miR-214-3p, mmu-miR-214-3p, dre-miR-214, and ssc-mir-214 [PMC4710718]. In PCMV-infected lung, liver, spleen, kidney, and thymus samples, ssc-mir-214 was found to be one of the most downregulated miRNAs compared to uninfected samples [PMC5774105]. It has also been identified as a downregulated hub miRNA in various contexts [PMC5796217]. Ssc-mir-214 has been associated with Salmonella infection and plays a role in the regulation of ovarian function and follicular development [PMC4521145] [PMC7912685]. In different tissues infected with various pathogens or under different conditions, ssc-mir-214 has shown both upregulation and downregulation compared to control samples [PMC5326932] [PMC4646468] [PMC8529057] [PMC8367414] [PMC10093425]. Ssc-mir-214 has been found to have regulatory effects on target genes involved in the VEGF signaling pathway as well as the HIF-1 related signaling pathway [PMC4646468] [ PMC8529057 ]. It is also involved in the regulation of target genes through miRNA-mRNA networks [ PMC10093425 ].
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