hsa-mir-381: Hsa-mir-381 is a microRNA that has been studied as a potential marker in various cancer models [PMC4951313]. In triple-negative breast cancer (TNBC), hsa-mir-381 is one of the microRNAs that correlated positively with PTEN-deficiency [PMC6357448]. Additionally, hsa-mir-381 is one of the miRNAs whose targets are significantly enriched in a list of cancer-related genes [PMC6604454]. It has also been predicted as a miRNA unrelated to the original training data in validation studies [PMC1159118]. Hsa-mir-381, along with other miRNAs such as hsa-miR-376a, hsa-miR-378, and hsa-miR-382, has clustered A-to-I editing sites reported in its coding genes [PMC5001599]. In breast cancer luminal A subtype, hsa-mir-381 is one of the identified miRNAs that could potentially modulate several pairs of pathways involved in various biological processes [PMC5123339]. Furthermore, differential expression of hsa-mir-381 has been observed between drug-sensitive and drug-resistant tissues [PMC4706521]. In osteosarcoma patients, high expression levels of hsa-mir-381 are associated with poor prognosis [PMC9553349]. References: [PMC6357448] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357448/ [PMC6604454] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604454/ [PMC1159118] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1159118/ [PMC4951313] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951313/ [PM5001599] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001599/ [PMC5123339] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123339/ [PMC4706521] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706521/ [PMC9553349] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553349/