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Homo sapiens (human) hsa-miR-326 URS00000A939F_9606

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hsa-mir-326: Hsa-mir-326 is a microRNA that has been studied in the context of cancer, specifically in resistant chronic myeloid leukemia (CML) patients [PMC2743636]. In a study comparing resistant and responder samples, it was found that 18 miRNAs, including hsa-mir-326, were down-regulated in resistant CML patients [PMC2743636]. Only one miRNA, hsa-miR-191, was found to be up-regulated in the resistant samples [PMC2743636]. The overexpression of hsa-mir-326 has been shown to have beneficial effects in animal models of non-small cell lung cancer (NSCLC), including decreased tumor growth, metastasis, and PD-L1 expression [PMC9659572]. Additionally, it was found to increase the infiltration of CD8+ cells and TNF-α+ IFN-γ+ CD8+ T-cells population in tumor tissues [PMC9659572]. In another analysis comparing responder and nonresponder samples, it was observed that responder samples had significantly elevated expression of hsa-mir-326 compared to nonresponder samples [PMC7794682]. These findings suggest that hsa-mir-326 may play a role in cancer resistance and response to treatment. Further research is needed to fully understand its mechanisms and potential therapeutic applications.

Genome locations

Gene Ontology annotations

Sequence

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CCUCUGGGCCCUUCCUCCAG

Taxonomic tree

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This sequence is found in 29 other species

  1. Bos taurus (cattle) bta-miR-326
  2. Canis lupus familiaris (dog) cfa-miR-326
  3. Cavia porcellus cpo-miR-326-3p
  4. Dasypus novemcinctus dno-miR-326-3p
  5. Echinops telfairi (small Madagascar hedgehog) Ete-Mir-326_3p (mature (guide))
  6. Gorilla gorilla gorilla ggo-miR-326 (MIR326)
  7. Gorilla gorilla ggo-miR-326
  8. Macaca fascicularis (crab-eating macaque) microRNA miR-326-3p
  9. Macaca mulatta Mml-Mir-326_3p (mature (guide))
  10. Mus musculus (house mouse) Mmu-Mir-326_3p (mature (guide))
  11. Oryctolagus cuniculus (rabbit) ocu-miR-326-3p
  12. Pan troglodytes (chimpanzee) ptr-miR-326
  13. Pongo pygmaeus ppy-miR-326
  14. Rattus norvegicus Rno-Mir-326_3p (mature (guide))
  15. Sus scrofa ssc-miR-326
Publications