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gga-mir-30a: gga-mir-30a is a microRNA (miRNA) that plays a significant role in the regulation of postnatal liver maturation in chickens, particularly by targeting the ESRP2 gene [PMC5758705]. This miRNA, along with gga-miR-30e, is highly expressed in the liver and is implicated in liver development [PMC5758705]. The gga-mir-30a sequence has been synthesized for research purposes and inserted into pmirGLO vectors to facilitate functional studies [PMC6406597]. It is also one of the top 20 miRNAs that are abundantly expressed in chicken somites, indicating its importance in chicken embryonic development [PMC4519947]. The gga-mir-30 family includes five members that share a common seed sequence but have unique 3′ ends, which allows them to target a slightly different set of genes [PMC7936154]. Specifically, gga-mir-30a has been found to influence skeletal muscle development by inhibiting myoblast proliferation during chick embryogenesis [PMC7936154]. Among differentially expressed miRNAs identified in Gallus gallus, gga-mir-30a was noted as the highest differentially expressed one, underscoring its significant regulatory role [PMC5214674].
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