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mmu-mir-30a: mmu-mir-30a is a microRNA that has been observed to be down-regulated in high-fat diet (HFD)-induced obesity in mice [PMC3319598]. Consistent with microarray data, RT-PCR results confirmed the downregulation of mmu-mir-30a in the context of obesity [PMC4346489]. This microRNA was also found to be differentially expressed in both plasma and aorta samples, indicating its potential role in atherosclerotic disease [PMC4346489]. Furthermore, mmu-mir-30a has been implicated in the regulation of brain-derived neurotrophic factor (BDNF) through direct targeting of its 3′UTR [PMC9120625]. In studies related to atherosclerotic vascular disease (ASVD), mmu-mir-30a was found to have a functional role through indirect regulation of SOCS3 and was significantly lower expressed in apoE−/− aortic tissues compared with healthy controls [PMC3641397]. Additionally, mmu-mir-30a expression was decreased in the prefrontal cortex and hippocampus of aged rats and is involved with innate immune system gene regulation [PMC6704709]. The regulatory elements for mmu-mir-30a have been identified, providing insights into its transcriptional control mechanisms [PMC6764145]. Lastly, alterations in mmu-mir-30a expression have been associated with liver regeneration processes and abnormal podocyte morphology when deficient [PMC9198802; PMC6032378].
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