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MIR27B: MIR27B is a microRNA that has been implicated in various biological processes and diseases [PMC5933288]. It has been found to play a role in thymic involution, with Wnt4 acting as a key inhibitor [PMC5933288]. In breast cancer, the reduction of MIR27B induced by CCL18 promotes invasion and migration of cancer cells [PMC4653020]. In patients with temporal lobe epilepsy (TLE), several miRNA families and clusters, including MIR27B, were found to be differentially methylated compared to controls [PMC9700089]. Additionally, MIR27B, along with miR-101 and miR-128, has been shown to downregulate VEGFC expression and suppress tumor growth, metastasis, invasion, migration, and angiogenesis in gastric cancer, bladder cancer, and hepatocellular carcinoma [PMC7780026]. Furthermore, it is suggested that MIR27B could directly regulate HIV-1 transcription [PMC3697138].
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