hsa-mir-217: Hsa-mir-217 is a microRNA that has been studied in relation to pancreatic ductal epithelium and heart fibrosis [PMC5441032] [PMC6406975]. In pancreatic ductal epithelium, the expression of hsa-mir-217 did not show a significant difference between PanIN1 and normal pancreatic ductal epithelium (NPDE) (P=0.159), but there was a significant decline in expression between PanIN1 and PanIN2 (P=0.028), as well as between PanIN2 and PanIN3 (P=0.011) [PMC5441032]. This suggests that hsa-mir-217 may play a role in the progression of pancreatic intraepithelial neoplasia (PanIN) [PMC5441032]. In the context of heart fibrosis, high expression of hsa-mir-217 in pathological rat cardiac myocytes (CMs) was found to promote its release through extracellular vesicles (EXOs). These EXOs were taken up by cardiac fibroblasts (CFs), leading to their proliferation and activation, ultimately contributing to heart fibrosis [PMC6406975]. This suggests that hsa-mir-217 may be involved in the pathological processes leading to cardiac fibrosis [PMC6406975]. Overall, these studies highlight the potential role of hsa-mir-217 in both pancreatic neoplasia and heart fibrosis [PMC5441032] [PMC6406975].