v26

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Ovis aries (sheep) oar-miR-181a secondary structure diagram

Ovis aries (sheep) oar-miR-181a URS00003DA300_9940

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oar-mir-181a: oar-mir-181a is a microRNA (miRNA) that exhibits high expression levels during the sheep breeding season and is implicated in sheep fecundity [PMC7992348]. It is correlated with various circular RNAs (circRNAs) that are involved in reproductive functions, and its expression is influenced by the breeding season, showing a decrease from early to pre-lambing [PMC8300399; PMC9679157]. Competitive endogenous RNA network analysis has revealed target miRNA sites for oar-mir-181a in circRNAs, indicating its regulatory role [PMC8300399]. oar-mir-181a has been found to be downregulated in sheep immunized with B. suis strain S2, suggesting a role in the immune response [PMC8902169]. It targets genes involved in innate immunity and has been validated by RT-qPCR as a marker miRNA for further studies [PMC8902169]. Despite its downregulation upon immunization, oar-mir-181a's expression levels are consistent with miRNA-seq results, confirming its regulatory significance [PMC8902169].

Genome locations

Gene Ontology annotations

Sequence

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AACAUUCAACGCUGUCGGUGAGU

Taxonomic tree

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This sequence is found in 60 other species

  1. Alligator mississippiensis (American alligator) ami-miR-181a-5p
  2. Anolis carolinensis aca-miR-181a
  3. Bos taurus (domestic cattle) Bta-Mir-181-P1b_5p (mature (guide))
  4. Callithrix jacchus cja-miR-181a
  5. Callorhinchus milii Cmi-Mir-181-P1c_5p (mature (guide))
  6. Canis lupus familiaris (dog) Cfa-Mir-181-P1b_5p (mature (guide))
  7. Capra hircus (goat) miR-181a
  8. Cavia porcellus Cpo-Mir-181-P1b_5p (mature (guide))
  9. Cervus elaphus cel-miR-181a
  10. Chrysemys picta bellii (western painted turtle) Cpi-Mir-181-P1b_5p (mature (guide))
  11. Chrysemys picta cpi-miR-181a-5p
  12. Columba livia Cli-Mir-181-P1b_5p (mature (guide))
  13. Cricetulus griseus (Chinese hamster) cgr-miR-181a-5p
  14. Danio rerio (zebrafish) dre-miR-181a-5p
  15. Dasypus novemcinctus Dno-Mir-181-P1b_5p (mature (guide))
  16. Daubentonia madagascariensis (aye-aye) dma-miR-181a
  17. Echinops telfairi (small Madagascar hedgehog) Ete-Mir-181-P1b_5p (mature (guide))
  18. Eptatretus burgeri Ebu-Mir-181-P1f_5p (mature (guide))
  19. Equus caballus eca-miR-181a
  20. Gadus morhua gmo-miR-181a-5p
  21. Gallus gallus (chicken) gga-miR-181a-5p
  22. Gekko japonicus Gja-Mir-181-P1b_5p (mature (guide))
  23. Gorilla gorilla gorilla ggo-miR-181a-5p (MIR181A-2)
  24. Gorilla gorilla ggo-miR-181a-5p
  25. Homo sapiens hsa-miR-181a-5p
  26. Lagothrix lagotricha (brown woolly monkey) lla-miR-181a-5p
  27. Latimeria chalumnae (coelacanth) Lch-Mir-181-P1b_5p (mature (guide))
  28. Lepisosteus oculatus (spotted gar) Loc-Mir-181-P1b_5p (mature (guide))
  29. Loxodonta africana (African savanna elephant) Laf-Mir-181-P1b_5p (mature (guide))
  30. Macaca mulatta (Rhesus monkey) mml-miR-181a-5p
  31. Macaca nemestrina mne-miR-181a-5p
  32. Microcaecilia unicolor Mun-Mir-181-P1b_5p (mature (guide))
  33. Microcebus murinus (gray mouse lemur) Mmr-Mir-181-P1b_5p (mature (guide))
  34. Monodelphis domestica (gray short-tailed opossum) mdo-miR-181a-5p
  35. Mus musculus mmu-miR-181a-5p
  36. Nomascus leucogenys (northern white-cheeked gibbon) nle-miR-181a
  37. Notamacropus eugenii (tammar wallaby) Neu-Mir-181-P1b_5p (mature (guide))
  38. Ornithorhynchus anatinus oan-miR-181a-5p
  39. Oryctolagus cuniculus Ocu-Mir-181-P1b_5p (mature (guide))
  40. Otolemur garnettii (small-eared galago) oga-miR-181a
  41. Pan paniscus ppa-miR-181a-5p
  42. Pan troglodytes (chimpanzee) ptr-miR-181a-5p
  43. Papio hamadryas (hamadryas baboon) pha-miR-181a
  44. Petromyzon marinus pma-miR-181a-5p
  45. Pongo abelii (Sumatran orangutan) Pab-Mir-181-P1b_5p (mature (guide))
  46. Pongo pygmaeus (Bornean orangutan) ppy-miR-181a-5p
  47. Python bivittatus (Burmese python) Pbv-Mir-181-P1c_5p (mature (guide))
  48. Rattus norvegicus rno-miR-181a-5p
  49. Saguinus labiatus (red-chested mustached tamarin) sla-miR-181a
  50. Salmo salar (Atlantic salmon) ssa-miR-181a-5p
  51. Sarcophilus harrisii (Tasmanian devil) Sha-Mir-181-P1b_5p (mature (guide))
  52. Scyliorhinus torazame (cloudy catshark) Sto-Mir-181-P1b_5p (mature (guide))
  53. Sphenodon punctatus Spt-Mir-181-P1b_5p (mature (guide))
  54. Taeniopygia guttata (zebra finch) tgu-miR-181a-5p
  55. Takifugu rubripes (torafugu) fru-miR-181a-5p
  56. Tetraodon nigroviridis (spotted green pufferfish) tni-miR-181a-5p
  57. Tor tambroides (Thai mahseer) miR-181a-5p
  58. Tupaia chinensis tch-miR-181a-5p
  59. Xenopus laevis (African clawed frog) Xla-Mir-181-P1a3_5p* (star (passenger))
  60. Xenopus tropicalis (tropical clawed frog) xtr-miR-181a-5p
 Relationships

Molecular Relationships

 2D structure

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 Publications