mmu-mir-134: Mmu-mir-134 is a microRNA that has been found to increase its expression significantly at different times post-infection [PMC9861972]. It has also been reported to be highly elevated in infected liver cells [PMC9861972]. Mmu-mir-134 has been selected as a candidate for functional verification [PMC9120625]. It has been shown to inhibit genes related to pluripotency, such as Nanog, Sox2, and Pou5f1, and participate in cell differentiation [PMC9505168]. Mmu-mir-134 has also been identified as a potential target of BDNF (Brain-Derived Neurotrophic Factor) by RNAhybrid analysis [PMC9120625]. Luciferase reporter assay confirmed that miR-134 can directly bind to BDNF 3'UTR (3' untranslated region) [PMC9120625]. Mmu-mir-134 is associated with the 'Mitotic Roles of Polo-Like-Kinase' pathway [PMC5220332]. It has also been validated as a degrader of Oct4 and Nanog proteins [PMC3937077]. Mmu-mir-134 is involved in the regulation of insulin secretion and the development of AD (Alzheimer's Disease) [PMC7041741] [PMC8036276] It regulates the development of cortical neurons and is involved in the transformation of neuronal progenitor cells into neuron-like cells [PMC6906698] It has also been shown to be downregulated in AD patients and regulates BACE1 expression, which is associated with disease progression in AD patients. The expression levels of mmu-mir-134 have been validated using real-time quantitative PCR with TaqMan miRNA assays.