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mmu-mir-142: Mmu-mir-142 is a microRNA that plays significant roles in immune regulation and various biological processes such as the development of nasopharynx carcinoma, cell cycling, IL-6 modulation in hematopoietic cell tissues, mature T cell proliferation, and endotoxin-induced mortality in inflammatory processes [Sun et al., 2011, 2013, 2015; PMC6176049]. It has been observed that mmu-mir-142 and mmu-miR-101 overexpression is related to γδT CD27+ (IL-17-) cells [PMC8234718]. Maternal immunization with OVA has been shown to influence the thymic expression of mmu-miR-15a, mmu-miR-101, mmu-miR-126, and mmu-mir-142 in offspring as part of the mechanism of IL-17-producing γδT cells inhibition [PMC8234718]. Additionally, highly significant CISs (common integration sites) have been found near genes such as Pik3r5 and Pik3cd that have not previously been linked to tumorigenesis [PMC2405818]. Microarray datasets from knockout experiments have shown the effects of mmu-mir-142 on its exclusive targets [PMC3919606]. Mmu-mir-142 has also been observed in studies related to Chlamydia pathogenesis [PMC6379932]. Both mmu-mir-142-3p and mmu-mir-142–5p are derived from the stem loop precursor of mmu-mir–142 [PMC3319598]. Furthermore, a study has connected mmu-mir–142 with obesity; however, further experiments are needed to elucidate its role in this process [PMC3319598].
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