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bta-mir-10a: Bta-mir-10a is a microRNA that has been found to be downregulated in the serum of cows with metritis compared to healthy cows [PMC7832875]. It has also been implicated in the regulation of milk somatic cell count (SCC), an indicator trait for mastitis, as well as in innate immune responses and lipid and cholesterol metabolism [PMC6008395]. Bta-mir-10a has been detected with relatively high read counts in both healthy and metritis cows, indicating its presence in both groups [PMC5617439]. It has also been found to be more abundant in myeloid-derived suppressor cells (MDSCs) compared to MDSC precursors [PMC5415838]. Bta-mir-10a is known to interact with genes such as RARB, RILPL1, PRKCA, ATF1, ABCA13, TBC1D19, MAGI2, and CUL5 [PMC4625573]. It is expressed abundantly in the duodenum and proximal jejunum of cows [PMC7959717]. In cows with metritis, bta-mir-10a is downregulated compared to control cows and may play a critical role in uterine inflammation [PMC4941693]. Bta-mir-10a is also shared among different groups of miRNAs both in vivo and in vitro [PMC6965648]. It has been associated with STAT3 signaling pathway [PMC9592977] and is highly enriched in extracellular vesicles (EVs) of different species including F. hepatica [PMC8036276]. Additionally, bta-mir-10a shows differential expression during post-weaning stages of cow development [PMC6162677] and is more abundant in MDSCs compared to MDSC precursors.
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