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Bos taurus (cattle) bta-miR-10a URS000016D2D4_9913

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bta-mir-10a: Bta-mir-10a is a microRNA that has been found to be downregulated in the serum of cows with metritis compared to healthy cows [PMC7832875]. It has also been implicated in the regulation of milk somatic cell count (SCC), an indicator trait for mastitis, as well as in innate immune responses and lipid and cholesterol metabolism [PMC6008395]. Bta-mir-10a has been detected with relatively high read counts in both healthy and metritis cows, indicating its presence in both groups [PMC5617439]. It has also been found to be more abundant in myeloid-derived suppressor cells (MDSCs) compared to MDSC precursors [PMC5415838]. Bta-mir-10a is known to interact with genes such as RARB, RILPL1, PRKCA, ATF1, ABCA13, TBC1D19, MAGI2, and CUL5 [PMC4625573]. It is expressed abundantly in the duodenum and proximal jejunum of cows [PMC7959717]. In cows with metritis, bta-mir-10a is downregulated compared to control cows and may play a critical role in uterine inflammation [PMC4941693]. Bta-mir-10a is also shared among different groups of miRNAs both in vivo and in vitro [PMC6965648]. It has been associated with STAT3 signaling pathway [PMC9592977] and is highly enriched in extracellular vesicles (EVs) of different species including F. hepatica [PMC8036276]. Additionally, bta-mir-10a shows differential expression during post-weaning stages of cow development [PMC6162677] and is more abundant in MDSCs compared to MDSC precursors.

Genome locations

Gene Ontology annotations

Sequence

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UACCCUGUAGAUCCGAAUUUGUG

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This sequence is found in 34 other species

  1. Alligator mississippiensis (American alligator) ami-miR-10a-5p
  2. Anolis carolinensis aca-miR-10a-5p
  3. Ateles geoffroyi age-miR-10a
  4. Branchiostoma floridae bfl-miR-10a-5p
  5. Branchiostoma lanceolatum (amphioxus) Bla-Mir-10-P1-v2_5p (mature (guide))
  6. Callorhinchus milii (elephant shark) Cmi-Mir-10-P1c-v1_5p (mature (guide))
  7. Capra hircus miR-10a
  8. Columba livia cli-miR-10a-5p
  9. Dasypus novemcinctus dno-miR-10a-5p
  10. Eisenia fetida (common brandling worm) Efe-Mir-10-P1i_5p (mature (guide))
  11. Equus caballus (horse) eca-miR-10a
  12. Gallus gallus (chicken) Gallus_gallus piRNA piR-gga-1287
  13. Gekko japonicus Gja-Mir-10-P1c-v1_5p (mature (guide))
  14. Gorilla gorilla (western gorilla) ggo-miR-10a
  15. Homo sapiens hsa-miR-10a-5p
  16. Hyalella azteca miR-10
  17. Macaca mulatta (Rhesus monkey) mml-miR-10a-5p
  18. Microcaecilia unicolor Mun-Mir-10-P1c-v1_5p (mature (guide))
  19. Monodelphis domestica mdo-miR-10a-5p
  20. Mus musculus (house mouse) mmu-miR-10a-5p
  21. Ophiophagus hannah (king cobra) oha-miR-10a-5p
  22. Ovis aries miscellaneous RNA
  23. Pan paniscus (pygmy chimpanzee) ppa-miR-10a
  24. Pan troglodytes ptr-miR-10a
  25. Pongo pygmaeus ppy-miR-10a
  26. Ptychodera flava Pfl-Mir-10-P1_5p (mature (guide))
  27. Python bivittatus (Burmese python) pbv-miR-10a-5p
  28. Rattus norvegicus rno-miR-10a-5p
  29. Saccoglossus kowalevskii sko-miR-10
  30. Saguinus labiatus sla-miR-10a
  31. Scyliorhinus torazame Sto-Mir-10-P1c-v1_5p (mature (guide))
  32. Sphenodon punctatus (tuatara) Spt-Mir-10-P1c_5p (mature (guide))
  33. Xenopus laevis Xla-Mir-10-P1c3-v1_5p (mature (guide))
  34. Xenopus tropicalis (tropical clawed frog) xtr-miR-10a
Publications