mmu-mir-10a: Mmu-mir-10a is a microRNA (miRNA) that is part of a series of miRNAs, including mmu-mir-146a and mmu-mir-10b, which were investigated in a study on knockout mice [PMC3797721]. The study utilized sequencing primers to analyze the gene desert on mouse chromosome 11 and quantified the ratios of digested/undigested bands [PMC3797721]. The researchers mated two independent heterozygous mice deficient for mmu-mir-10a and -10b with wild type mice to examine the transmission of mutated alleles to the next generation [PMC3797721]. TALENs were constructed for specific gene desert regions, including mmu-mir-146a, mmu-mir-10a, and mmu-mir -10b [PMC3797721]. In a mouse leukemia model, miRNA variants of mmu-mir-10a were found to be differentially expressed across disease and normal conditions [PMC3919606]. Mmu-mir-10a is part of a paralogous sequence with mmu-miR-10b in mice [PMC4075084]. Additionally, several miRNAs including mmu-miR-761, mmu-miR-214, and mmu-miR-339 were predicted to bind four sites within 3′UTR using various tools [PMC4902921]. Overall, these findings contribute to our understanding of the role of Mmu-MIR-10a in gene regulation.
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