hsa-mir-151a: Hsa-mir-151a is a microRNA that has been found to be differentially expressed in various studies. It has been shown to be highly expressed in network analysis studies [PMC8903000]. Additionally, hsa-mir-151a has been associated with Helicobacter pylori (H. pylori) infection [PMC9409130]. In lung adenocarcinoma (LAC) patients, hsa-mir-151a is significantly overexpressed in NSCLC tissue compared to normal tissue [PMC5541717]. The expression level of hsa-mir-151a is downregulated following MG induction [PMC7393356]. Hsa-mir-151a has also been found to modulate genes involved in various pathways, including adherens, angiogenesis, cell cycle, and wound healing pathways [PMC7393356]. It has been shown to target the transcript ENST00000292174 that encodes for C–X–C motif chemokine receptor protein [PMC7393356]. Hsa-mir-151a promotes metastasis and inhibits RhoGDIA by functioning synergistically with FAK [PMC8486515]. It has also been identified as a putative shared miRNA eQTL and miRNA eQTLs that appear to be shared between cells and exosomes [PMC5217120]. Hsa-mir-151a is differentially regulated genes involved in cell adhesion, angiogenesis, cell cycle, JAK-STAT signaling, MAPK signaling, NO signaling, and VEGF signaling pathways favoring angiogenesis [PMC8493071]. However, the confirmation of hsa-mir-151a as a microRNA was not successful in some studies [PMC5675613]. Overall, hsa-mir-151a plays a significant role in various biological processes and disease conditions.

hsa-mir-28: hsa-mir-28 is a microRNA that is over-expressed in resting CD4+T cells and has been reported to target the 3' end of human HIV-1 RNA, leading to the silencing of viral proteins [PMC4070032]. In a study comparing MMVP specimens and FED samples, it was found that the expression of hsa-mir-28 was lower in MMVP specimens [PMC4881574]. Several articles have indicated that hsa-mir-28-5p has inhibitory activity in vitro, suggesting its potential role in tumor suppression [PMC8752235]. hsa-mir-28, along with hsa-miR-548 family, has been identified as being derived from genetic elements [PMC2952848]. Among the 10 most highly expressed miRNAs, hsa-mir-28 appeared only once in tenth place [PMC4486185].