Caution, this is an AI generated summary based on literature. This may have errors, see here for more.
Please share your feedback with us.
mmu-mir-192: Mmu-mir-192 is a microRNA that has been studied in the context of high-fat diet (HFD)-induced obesity. In a microarray experiment, it was found that mmu-mir-192 was downregulated in white adipose tissue (WAT) in response to HFD feeding [1]. This downregulation of mmu-mir-192 was also observed in another study on HFD-induced obesity [2]. The downregulation of mmu-mir-192 is described for the first time and requires further investigation [2]. Mmu-mir-192 has been found to target Zeb1 and Zeb2, which regulate epithelial to mesenchymal transition [2]. Mmu-mir-192 is highly expressed in both the small and large intestine [3]. In a study on non-alcoholic fatty liver disease (NAFLD), it was found that liver cells exposed to excessive lipids released exosomes containing higher amounts of mmu-miR-122 and mmu-mir-192 [4]. The loss of mmu-mir-192 has been associated with impaired intestinal barrier function and spontaneous intestinal inflammation [5] [6]. In another study, mmu-miR-192 was found to be downregulated, along with other miRNAs, in response to a specific treatment [7].
References:
[1] PMC4571067
[2] PMC3319598
[3] PMC5618556
[4] PMC7936154
[5] PMC4292042
[6] PMC7426649
[7] PMC9198802
Genome locations
Gene Ontology annotations
Ancestor Chart
Loading ontology ancestors...
Failed to load QuickGO Ancestor chart
Sequence
Sequence features are shown above as colored rectangles.
Zoom in and click to view details, or
Reset