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Mus musculus (house mouse) mmu-miR-192-5p URS0000155642_10090

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mmu-mir-192: Mmu-mir-192 is a microRNA that has been studied in the context of high-fat diet (HFD)-induced obesity. In a microarray experiment, it was found that mmu-mir-192 was downregulated in white adipose tissue (WAT) in response to HFD feeding [1]. This downregulation of mmu-mir-192 was also observed in another study on HFD-induced obesity [2]. The downregulation of mmu-mir-192 is described for the first time and requires further investigation [2]. Mmu-mir-192 has been found to target Zeb1 and Zeb2, which regulate epithelial to mesenchymal transition [2]. Mmu-mir-192 is highly expressed in both the small and large intestine [3]. In a study on non-alcoholic fatty liver disease (NAFLD), it was found that liver cells exposed to excessive lipids released exosomes containing higher amounts of mmu-miR-122 and mmu-mir-192 [4]. The loss of mmu-mir-192 has been associated with impaired intestinal barrier function and spontaneous intestinal inflammation [5] [6]. In another study, mmu-miR-192 was found to be downregulated, along with other miRNAs, in response to a specific treatment [7]. References: [1] PMC4571067 [2] PMC3319598 [3] PMC5618556 [4] PMC7936154 [5] PMC4292042 [6] PMC7426649 [7] PMC9198802

Genome locations

Gene Ontology annotations

Sequence

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CUGACCUAUGAAUUGACAGCC

Taxonomic tree

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This sequence is found in 43 other species

  1. Bos taurus Bta-Mir-192-P2_5p (mature (guide))
  2. Canis lupus familiaris (dog) cfa-miR-192
  3. Capra hircus chi-miR-192-5p
  4. Cavia porcellus (domestic guinea pig) cpo-miR-192-5p
  5. Cervus elaphus cel-miR-192
  6. Echinops telfairi Ete-Mir-192-P2_5p (mature (guide))
  7. Equus caballus (horse) eca-miR-192
  8. Gorilla gorilla gorilla ggo-miR-192 (MIR192)
  9. Gorilla gorilla ggo-miR-192
  10. Homo sapiens hsa-miR-192-5p
  11. Macaca mulatta (Rhesus monkey) mml-miR-192-5p
  12. Nomascus leucogenys (northern white-cheeked gibbon) nle-miR-192
  13. Ornithorhynchus anatinus (platypus) oan-miR-192-5p
  14. Oryctolagus cuniculus (rabbit) Ocu-Mir-192-P2_5p (mature (guide))
  15. Otolemur garnettii (small-eared galago) oga-miR-192
  16. Pan paniscus ppa-miR-192
  17. Pan troglodytes ptr-miR-192
  18. Pongo pygmaeus (Bornean orangutan) ppy-miR-192
  19. Rattus norvegicus rno-miR-192-5p
  20. Sarcophilus harrisii (Tasmanian devil) Sha-Mir-192-P2_5p (mature (guide))
  21. Sus scrofa (pig) ssc-miR-192
  22. Tupaia chinensis tch-miR-192-5p
Publications