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rno-mir-200b: Rno-mir-200b is a rat miRNA that is a homolog of the human miRNA hsa-miR-200b [PMC4693154]. It has been identified as an early marker for the prediction of a carcinogenic potential [PMC4022579]. Rno-mir-200b is part of the miR-200 family, along with rno-miR-200a and rno-miR-200c, which have slight sequence variations compared to rno-mir-200b [PMC3895276]. Rno-mir-200b and rno-miR-429 have been predicted to target Zeb1, a gene associated with cancer [PMC8914318]. In an experiment with CCI rats, the expression of Zeb1 was significantly increased, while the expression of rno-mir-200b and rno-miR-429 was notably downregulated [PMC8914318]. However, overexpression of rno-mir-200b and rno-miR-429 led to a significant inhibition of Zeb1 mRNA expression in rats [PMC8914318]. These findings suggest that rno-mir-200b may play a role in cancer development and progression.
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