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hsa-mir-551b: Hsa-mir-551b is a microRNA that has been studied in various types of cancer, including lung adenocarcinoma, colorectal cancer, gastric cancer, cholangiocarcinoma, osteosarcoma, hepatocellular carcinoma, and papillary thyroid carcinoma [PMC6563032][PMC8994656]. It has been shown to have different functions in different types of cancer. In lung adenocarcinoma and colorectal cancer, hsa-mir-551b is believed to regulate tumor progression [PMC6563032]. In gastric cancer, hsa-mir-551b-3p is downregulated and may serve as a tumor suppressor [PMC6563032][PMC6129036]. In cholangiocarcinoma cells, hsa-mir-551b-3p inhibits cell growth by targeting Cyclin D1 [PMC6129036][PMC8994656]. Additionally, hsa-mir-551b has been found to be downregulated in colorectal cancer tissues and may function as an anti-oncogene [PMC6129036]. It has also been associated with epithelial-to-mesenchymal transition (EMT), metastasis, and poor prognosis in gastric cancer patients [PMC6129036]. Furthermore, hsa-mir-551b has been predicted to be an upstream regulator of CCND1 [PMC6129036]. Overall, the role of hsa-mir-551b in various cancers is still not fully understood and further studies are needed to elucidate its function within the gene networks of these cancers.
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